The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RRP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:43,659,125–43,659,916 | 130.0 kb | Distal (>10kb) Multiome | 989 | |
| chr21:43,718,478–43,719,766 | 70.4 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,728,503–43,729,213 | 60.7 kb | Distal (>10kb) Multiome | 905 | |
| chr21:43,740,577–43,741,104 | 48.7 kb | Distal (>10kb) Multiome | 198 | |
| chr21:43,775,786–43,776,893 | 13.1 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,788,879–43,790,067 | 104 bp | At TSS Multiome | 930 | |
| chr21:43,864,215–43,864,709 | 74.8 kb | Distal (>10kb) Multiome | 538 | |
| chr21:43,865,135–43,865,798 | 75.9 kb | Distal (>10kb) Multiome | 333 | |
| chr21:43,883,997–43,884,476 | 94.7 kb | Distal (>10kb) Multiome | 418 | |
| chr21:43,921,393–43,922,764 | 132.4 kb | Distal (>10kb) Multiome | 622 | |
| chr21:44,011,848–44,013,192 | 223.0 kb | Distal (>10kb) Multiome | 873 |
Genomic view of the RRP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.