Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and tumor necrosis factor-mediated signaling pathway. Located in GATOR1 complex; lysosome; and nucleoplasm. Part of FNIP-folliculin RagC/D GAP. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RRAGA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRAGA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRAGA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:17,571,445–17,572,342 | 1477.5 kb | Distal (>10kb) Multiome HiCAR | 115 | |
| chr9:17,578,545–17,579,893 | 1470.3 kb | Distal (>10kb) Multiome HiCAR | 439 | |
| chr9:17,800,095–17,801,499 | 1248.6 kb | Distal (>10kb) Multiome HiCAR | 151 | |
| chr9:18,761,619–18,762,366 | 287.4 kb | Distal (>10kb) Multiome | 131 | |
| chr9:19,048,607–19,050,217 | 113 bp | At TSS Multiome | 993 | |
| chr9:19,102,191–19,103,414 | 53.5 kb | Distal (>10kb) Multiome | 770 | |
| chr9:19,126,915–19,128,564 | 78.1 kb | Distal (>10kb) Multiome | 808 | |
| chr9:19,201,888–19,203,074 | 153.0 kb | Distal (>10kb) Multiome | 569 | |
| chr9:19,229,553–19,231,458 | 181.1 kb | Distal (>10kb) Multiome | 973 |
Genomic view of the RRAGA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.