Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPUSD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPUSD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPUSD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,323,099–40,324,127 | 245.8 kb | Distal (>10kb) Multiome | 737 | |
| chr15:40,357,707–40,358,772 | 211.1 kb | Distal (>10kb) Multiome | 515 | |
| chr15:40,367,875–40,368,398 | 201.1 kb | Distal (>10kb) Multiome | 846 | |
| chr15:40,405,523–40,406,103 | 163.6 kb | Distal (>10kb) Multiome | 672 | |
| chr15:40,440,664–40,441,222 | 128.4 kb | Distal (>10kb) Multiome | 440 | |
| chr15:40,470,654–40,471,315 | 98.4 kb | Distal (>10kb) Multiome | 463 | |
| chr15:40,511,458–40,512,083 | 57.6 kb | Distal (>10kb) Multiome | 646 | |
| chr15:40,564,928–40,565,323 | 4.0 kb | Proximal (<10kb) | 573 | |
| chr15:40,569,163–40,569,414 | at TSS | At TSS | 651 | |
| chr15:40,593,777–40,594,776 | 24.8 kb | Distal (>10kb) Multiome | 899 | |
| chr15:40,694,639–40,695,262 | 125.7 kb | Distal (>10kb) Multiome | 831 | |
| chr15:40,754,834–40,755,729 | 186.0 kb | Distal (>10kb) Multiome | 816 | |
| chr15:40,806,990–40,807,956 | 238.3 kb | Distal (>10kb) Multiome | 782 | |
| chr15:40,843,756–40,844,502 | 274.8 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the RPUSD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.