Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RPS6KL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS6KL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS6KL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:74,763,078–74,763,795 | 159.9 kb | Distal (>10kb) Multiome | 808 | |
| chr14:74,881,522–74,882,475 | 41.4 kb | Distal (>10kb) Multiome | 877 | |
| chr14:74,922,804–74,923,467 | 14 bp | At TSS Multiome | 458 | |
| chr14:74,955,358–74,956,099 | 32.4 kb | Distal (>10kb) Multiome | 457 | |
| chr14:75,002,395–75,003,398 | 79.5 kb | Distal (>10kb) Multiome | 767 | |
| chr14:75,050,911–75,051,628 | 128.1 kb | Distal (>10kb) Multiome | 749 | |
| chr14:75,063,590–75,064,414 | 140.8 kb | Distal (>10kb) Multiome | 518 | |
| chr14:75,069,008–75,070,183 | 146.3 kb | Distal (>10kb) Multiome | 874 | |
| chr14:75,126,669–75,127,381 | 203.7 kb | Distal (>10kb) Multiome | 888 | |
| chr14:75,176,098–75,177,235 | 253.6 kb | Distal (>10kb) Multiome | 975 |
Genomic view of the RPS6KL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.