This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for RPS6KB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS6KB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS6KB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,239,493–67,240,241 | 188.5 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 162.0 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 139.3 kb | Distal (>10kb) Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 125.0 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 110.7 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,352,967–67,354,228 | 74.8 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,372,171–67,373,596 | 55.4 kb | Distal (>10kb) Multiome | 497 | |
| chr11:67,391,276–67,392,428 | 36.6 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,401,038–67,402,351 | 26.6 kb | Distal (>10kb) Multiome | 741 | |
| chr11:67,420,418–67,421,666 | 7.2 kb | Proximal (<10kb) Multiome | 648 | |
| chr11:67,428,036–67,428,950 | 39 bp | At TSS Multiome | 813 | |
| chr11:67,443,182–67,444,063 | 15.2 kb | Distal (>10kb) Multiome | 612 | |
| chr11:67,464,410–67,465,252 | 36.3 kb | Distal (>10kb) Multiome | 710 | |
| chr11:67,468,551–67,469,666 | 40.8 kb | Distal (>10kb) Multiome | 774 | |
| chr11:67,482,830–67,483,745 | 54.7 kb | Distal (>10kb) Multiome | 969 | |
| chr11:67,504,073–67,506,408 | 77.9 kb | Distal (>10kb) Multiome | 769 | |
| chr11:67,507,504–67,509,030 | 79.9 kb | Distal (>10kb) Multiome | 897 | |
| chr11:67,583,474–67,584,777 | 155.3 kb | Distal (>10kb) Multiome | 633 | |
| chr11:67,606,302–67,607,213 | 178.4 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,614,064–67,614,626 | 185.8 kb | Distal (>10kb) Multiome | 383 | |
| chr11:67,619,429–67,620,391 | 191.4 kb | Distal (>10kb) Multiome | 50 | |
| chr11:67,628,876–67,631,242 | 201.9 kb | Distal (>10kb) Multiome | 1018 |
Genomic view of the RPS6KB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.