This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPS6KA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS6KA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS6KA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,233,613–26,234,924 | 295.7 kb | Distal (>10kb) Multiome | 867 | |
| chr1:26,275,604–26,276,096 | 254.0 kb | Distal (>10kb) Multiome | 373 | |
| chr1:26,279,438–26,280,566 | 249.8 kb | Distal (>10kb) Multiome | 820 | |
| chr1:26,306,331–26,306,935 | 223.1 kb | Distal (>10kb) Multiome | 563 | |
| chr1:26,335,993–26,337,256 | 193.2 kb | Distal (>10kb) Multiome | 655 | |
| chr1:26,360,031–26,360,668 | 169.4 kb | Distal (>10kb) Multiome | 164 | |
| chr1:26,409,125–26,412,949 | 119.3 kb | Distal (>10kb) Multiome | 517 | |
| chr1:26,416,811–26,417,349 | 112.6 kb | Distal (>10kb) Multiome | 290 | |
| chr1:26,418,111–26,419,646 | 110.6 kb | Distal (>10kb) Multiome | 189 | |
| chr1:26,431,868–26,432,811 | 97.5 kb | Distal (>10kb) Multiome | 1083 | |
| chr1:26,471,339–26,473,364 | 56.8 kb | Distal (>10kb) Multiome | 992 | |
| chr1:26,500,060–26,501,704 | 29.4 kb | Distal (>10kb) Multiome | 1028 | |
| chr1:26,529,200–26,531,855 | 1.6 kb | Proximal (<10kb) Multiome | 703 | |
| chr1:26,620,089–26,621,718 | 90.9 kb | Distal (>10kb) Multiome | 1174 | |
| chr1:26,692,203–26,693,499 | 162.7 kb | Distal (>10kb) Multiome | 974 | |
| chr1:26,695,271–26,696,473 | 165.9 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:26,723,135–26,723,892 | 193.8 kb | Distal (>10kb) Multiome | 671 | |
| chr1:26,786,686–26,788,664 | 258.2 kb | Distal (>10kb) Multiome | 918 | |
| chr1:26,826,166–26,827,148 | 296.9 kb | Distal (>10kb) Multiome | 510 |
Genomic view of the RPS6KA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.