Transcription factors with Perturb-seq knockdown data for RPS2P17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS2P17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS2P17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:84,904,641–84,908,593 | 7.3 kb | Proximal (<10kb) | 1075 | |
| chr2:84,908,880–84,909,480 | 6.4 kb | Proximal (<10kb) | 146 | |
| chr2:84,924,763–84,925,080 | 8.9 kb | Proximal (<10kb) | 121 | |
| chr2:84,925,524–84,927,306 | 9.7 kb | Proximal (<10kb) | 1034 |
Genomic view of the RPS2P17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.