Transcription factors with Perturb-seq knockdown data for RPS28P7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS28P7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS28P7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:82,680,161–82,680,523 | 9.0 kb | Proximal (<10kb) | 103 | |
| chr11:82,682,285–82,683,371 | 6.2 kb | Proximal (<10kb) | 329 | |
| chr11:82,693,058–82,693,715 | 3.5 kb | Proximal (<10kb) | 17 | |
| chr11:82,695,267–82,696,305 | 5.7 kb | Proximal (<10kb) | 385 |
Genomic view of the RPS28P7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.