Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in fibrillar center. Part of multimeric ribonuclease P complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPP38. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPP38 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPP38, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:14,837,437–14,839,368 | 259.2 kb | Distal (>10kb) Multiome | 908 | |
| chr10:14,877,852–14,879,824 | 218.6 kb | Distal (>10kb) Multiome | 977 | |
| chr10:14,952,697–14,954,554 | 144.3 kb | Distal (>10kb) Multiome | 1101 | |
| chr10:14,959,013–14,960,243 | 137.8 kb | Distal (>10kb) Multiome | 879 | |
| chr10:15,088,358–15,089,070 | 8.6 kb | Proximal (<10kb) Multiome | 622 | |
| chr10:15,096,597–15,098,027 | 126 bp | At TSS Multiome | 949 | |
| chr10:15,106,421–15,106,698 | 9.2 kb | Proximal (<10kb) | 277 | |
| chr10:15,167,406–15,169,756 | 71.5 kb | Distal (>10kb) Multiome | 796 | |
| chr10:15,370,316–15,371,740 | 273.9 kb | Distal (>10kb) Multiome | 451 |
Genomic view of the RPP38 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.