RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]
Transcription factors with Perturb-seq knockdown data for RPP21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPP21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPP21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,060,737–30,061,999 | 283.9 kb | Distal (>10kb) Multiome | 973 | |
| chr6:30,066,588–30,067,716 | 278.0 kb | Distal (>10kb) Multiome | 952 | |
| chr6:30,101,800–30,102,573 | 243.0 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,103,094–30,103,626 | 241.8 kb | Distal (>10kb) Multiome | 616 | |
| chr6:30,171,597–30,172,574 | 173.2 kb | Distal (>10kb) Multiome | 185 | |
| chr6:30,207,044–30,207,811 | 137.8 kb | Distal (>10kb) Multiome | 514 | |
| chr6:30,212,953–30,213,888 | 131.7 kb | Distal (>10kb) Multiome | 826 | |
| chr6:30,213,977–30,214,728 | 130.6 kb | Distal (>10kb) Multiome | 758 | |
| chr6:30,259,131–30,260,199 | 85.6 kb | Distal (>10kb) Multiome | 475 | |
| chr6:30,325,606–30,327,611 | 18.2 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:30,344,843–30,345,715 | 88 bp | At TSS Multiome | 892 | |
| chr6:30,357,696–30,358,238 | 12.7 kb | Distal (>10kb) Multiome | 207 | |
| chr6:30,466,230–30,466,713 | 121.4 kb | Distal (>10kb) Multiome | 369 | |
| chr6:30,489,117–30,490,512 | 145.2 kb | Distal (>10kb) Multiome | 750 | |
| chr6:30,516,006–30,516,707 | 171.2 kb | Distal (>10kb) Multiome | 739 | |
| chr6:30,555,407–30,557,765 | 211.5 kb | Distal (>10kb) Multiome | 1161 | |
| chr6:30,570,822–30,571,949 | 226.3 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:30,614,393–30,615,939 | 270.0 kb | Distal (>10kb) Multiome | 837 | |
| chr6:30,616,770–30,618,155 | 272.4 kb | Distal (>10kb) Multiome | 1072 | |
| chr6:30,626,560–30,627,206 | 281.7 kb | Distal (>10kb) Multiome | 802 |
Genomic view of the RPP21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.