This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for RPN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:36,886,953–36,887,714 | 292.0 kb | Distal (>10kb) Multiome | 586 | |
| chr20:36,951,062–36,952,347 | 227.6 kb | Distal (>10kb) Multiome | 859 | |
| chr20:37,095,487–37,096,500 | 83.5 kb | Distal (>10kb) Multiome | 1181 | |
| chr20:37,178,302–37,178,487 | 672 bp | At TSS | 574 | |
| chr20:37,178,598–37,179,693 | 224 bp | At TSS Multiome | 977 | |
| chr20:37,289,329–37,289,991 | 110.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr20:37,319,185–37,319,833 | 140.2 kb | Distal (>10kb) Multiome | 87 | |
| chr20:37,345,682–37,346,478 | 166.7 kb | Distal (>10kb) Multiome | 557 | |
| chr20:37,396,207–37,397,008 | 217.3 kb | Distal (>10kb) Multiome | 227 |
Genomic view of the RPN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.