Transcription factors with Perturb-seq knockdown data for RPL34P24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL34P24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL34P24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:17,135,990–17,136,348 | 1.9 kb | Proximal (<10kb) | 57 | |
| chr11:17,140,081–17,140,244 | 1.8 kb | Proximal (<10kb) | 2 | |
| chr11:17,140,897–17,141,442 | 2.6 kb | Proximal (<10kb) | 103 | |
| chr11:17,142,303–17,142,449 | 4.0 kb | Proximal (<10kb) | 7 |
Genomic view of the RPL34P24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.