This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for RPAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:46,267,263–46,270,142 | 1436.9 kb | Distal (>10kb) Multiome HiCAR | 1114 | |
| chr12:47,636,966–47,637,678 | 68.7 kb | Distal (>10kb) Multiome | 111 | |
| chr12:47,705,453–47,706,210 | 51 bp | At TSS Multiome | 859 | |
| chr12:47,715,163–47,715,746 | 9.2 kb | Proximal (<10kb) | 212 | |
| chr12:47,717,388–47,718,196 | 11.8 kb | Distal (>10kb) Multiome | 330 | |
| chr12:47,757,825–47,759,674 | 53.2 kb | Distal (>10kb) Multiome | 644 | |
| chr12:47,772,964–47,774,017 | 67.3 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr12:47,778,984–47,779,897 | 73.5 kb | Distal (>10kb) Multiome HiCAR | 320 | |
| chr12:47,812,831–47,813,817 | 107.1 kb | Distal (>10kb) Multiome | 555 | |
| chr12:47,818,868–47,821,142 | 114.0 kb | Distal (>10kb) Multiome | 777 | |
| chr12:47,904,573–47,905,755 | 199.2 kb | Distal (>10kb) Multiome | 575 | |
| chr12:47,942,159–47,942,641 | 236.5 kb | Distal (>10kb) Multiome | 160 | |
| chr12:47,963,134–47,964,083 | 257.6 kb | Distal (>10kb) Multiome | 742 | |
| chr12:48,000,982–48,002,307 | 295.6 kb | Distal (>10kb) Multiome | 379 | |
| chr12:48,003,968–48,005,434 | 298.6 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the RPAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.