Transcription factors with Perturb-seq knockdown data for RNU5E-6P. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNU5E-6P upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNU5E-6P, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:44,812,965–44,814,105 | 5.9 kb | Proximal (<10kb) | 349 | |
| chr1:44,815,061–44,815,277 | 4.7 kb | Proximal (<10kb) | 94 | |
| chr1:44,818,937–44,820,693 | at TSS | At TSS | 1101 | |
| chr1:44,827,370–44,827,546 | 7.4 kb | Proximal (<10kb) | 275 |
Genomic view of the RNU5E-6P locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.