Enables RNA binding activity and mRNA 5'-cap (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap methyltransferase RNMT:RAMAC complex; mRNA capping enzyme complex; and receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:13,611,713–13,612,773 | 114.3 kb | Distal (>10kb) Multiome | 250 | |
| chr18:13,685,070–13,685,819 | 41.2 kb | Distal (>10kb) Multiome | 16 | |
| chr18:13,725,789–13,727,337 | 113 bp | At TSS Multiome | 958 | |
| chr18:13,800,631–13,801,538 | 74.5 kb | Distal (>10kb) Multiome | 364 | |
| chr18:13,808,390–13,810,221 | 83.0 kb | Distal (>10kb) Multiome | 183 | |
| chr18:13,823,775–13,824,421 | 97.4 kb | Distal (>10kb) Multiome | 421 |
Genomic view of the RNMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.