Enables ubiquitin binding activity and ubiquitin protein ligase activity. Involved in positive regulation of ERAD pathway and protein autoubiquitination. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNFT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNFT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNFT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:59,707,078–59,708,143 | 257.2 kb | Distal (>10kb) Multiome | 963 | |
| chr17:59,837,406–59,838,036 | 127.0 kb | Distal (>10kb) Multiome | 865 | |
| chr17:59,892,295–59,893,854 | 71.7 kb | Distal (>10kb) Multiome | 992 | |
| chr17:59,964,460–59,965,228 | 101 bp | At TSS Multiome | 834 | |
| chr17:60,037,145–60,037,598 | 72.6 kb | Distal (>10kb) Multiome | 592 | |
| chr17:60,078,377–60,079,189 | 114.1 kb | Distal (>10kb) Multiome | 765 | |
| chr17:60,135,208–60,135,905 | 170.9 kb | Distal (>10kb) Multiome | 832 | |
| chr17:60,139,659–60,140,250 | 175.2 kb | Distal (>10kb) Multiome | 847 | |
| chr17:60,142,132–60,142,546 | 177.5 kb | Distal (>10kb) Multiome | 250 | |
| chr17:60,142,949–60,143,382 | 178.3 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the RNFT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.