The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:25,977,016–25,977,600 | 245.0 kb | Distal (>10kb) Multiome | 163 | |
| chr13:25,977,740–25,978,960 | 243.8 kb | Distal (>10kb) Multiome | 191 | |
| chr13:26,050,068–26,052,550 | 170.2 kb | Distal (>10kb) Multiome | 468 | |
| chr13:26,186,100–26,186,936 | 35.7 kb | Distal (>10kb) Multiome | 821 | |
| chr13:26,221,461–26,222,628 | 402 bp | At TSS Multiome | 979 | |
| chr13:26,253,747–26,254,977 | 31.8 kb | Distal (>10kb) Multiome | 742 | |
| chr13:26,475,352–26,476,527 | 253.5 kb | Distal (>10kb) Multiome | 241 |
Genomic view of the RNF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.