RNF31
ring finger protein 31 | FLJ10111, FLJ23501, HOIP, Paul, ZIBRA

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Biological processes 36 terms
CD40 receptor complex (GO:0035631)CD40 receptor complex (GO:0035631)CD40 signaling pathway (GO:0023035)CD40 signaling pathway (GO:0023035)K48-linked polyubiquitin modification-dependent protein binding (GO:0036435)K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)LUBAC complex (GO:0071797)LUBAC complex (GO:0071797)T cell receptor signaling pathway (GO:0050852)cell surface receptor signaling pathway (GO:0007166)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)cytosol (GO:0005829)defense response to bacterium (GO:0042742)identical protein binding (GO:0042802)linear polyubiquitin binding (GO:1990450)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of protein localization to mitochondrion (GO:1903749)positive regulation of xenophagy (GO:1904417)protein binding (GO:0005515)protein linear polyubiquitination (GO:0097039)protein linear polyubiquitination (GO:0097039)protein polyubiquitination (GO:0000209)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)ubiquitin binding (GO:0043130)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase binding (GO:0031625)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)zinc ion binding (GO:0008270)
Expression (TPM)
RNF31 — as a Regulated Gene

TFs regulating RNF31 0 TFs

Transcription factors with Perturb-seq knockdown data for RNF31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RNF31

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:23,910,478–23,911,853 236.7 kb Distal (>10kb) Multiome 310
chr14:23,953,479–23,954,293 193.7 kb Distal (>10kb) Multiome 897
chr14:23,988,469–23,989,172 158.7 kb Distal (>10kb) Multiome 439
chr14:24,036,218–24,036,993 111.0 kb Distal (>10kb) Multiome 627
chr14:24,051,239–24,052,875 95.6 kb Distal (>10kb) Multiome 821
chr14:24,080,914–24,082,038 66.0 kb Distal (>10kb) Multiome 706
chr14:24,093,491–24,095,115 53.3 kb Distal (>10kb) Multiome 990
chr14:24,113,681–24,115,917 32.5 kb Distal (>10kb) Multiome 1166
chr14:24,135,549–24,136,884 11.4 kb Distal (>10kb) Multiome 778
chr14:24,140,526–24,142,331 5.8 kb Proximal (<10kb) Multiome 1034
chr14:24,146,204–24,148,108 687 bp At TSS Multiome 918
chr14:24,160,877–24,161,762 13.7 kb Distal (>10kb) Multiome 970
chr14:24,171,489–24,172,698 24.4 kb Distal (>10kb) Multiome 365
chr14:24,188,229–24,189,111 41.3 kb Distal (>10kb) Multiome 1074
chr14:24,195,072–24,196,365 48.1 kb Distal (>10kb) Multiome 1059
chr14:24,212,871–24,213,884 65.9 kb Distal (>10kb) Multiome 1036
chr14:24,215,523–24,216,241 68.5 kb Distal (>10kb) Multiome 955
chr14:24,231,706–24,233,147 85.1 kb Distal (>10kb) Multiome 1027
chr14:24,241,845–24,243,572 95.1 kb Distal (>10kb) Multiome 1077
chr14:24,270,770–24,271,924 123.9 kb Distal (>10kb) Multiome 1089
chr14:24,299,120–24,300,273 152.3 kb Distal (>10kb) Multiome 892
chr14:24,315,948–24,316,753 168.9 kb Distal (>10kb) Multiome 736
chr14:24,332,251–24,333,127 185.0 kb Distal (>10kb) Multiome 740
chr14:24,365,652–24,366,243 218.2 kb Distal (>10kb) Multiome 668
chr14:24,366,594–24,369,358 219.7 kb Distal (>10kb) Multiome 921
chr14:24,388,547–24,389,510 241.5 kb Distal (>10kb) Multiome 161
chr14:24,398,424–24,399,423 251.4 kb Distal (>10kb) Multiome 354
chr14:24,429,597–24,431,070 282.6 kb Distal (>10kb) Multiome 903
chr14:24,431,554–24,432,205 284.4 kb Distal (>10kb) Multiome 604
chr14:24,441,935–24,443,373 295.1 kb Distal (>10kb) Multiome 1072

Genome Browser

Genomic view of the RNF31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:23,900,478 – 24,453,373
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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