RNF207
ring finger protein 207 | FLJ32096, FLJ46380, C1orf188

Enables Hsp70 protein binding activity and transmembrane transporter binding activity. Involved in positive regulation of gene expression. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 21 terms
Hsp70 protein binding (GO:0030544)Hsp70 protein binding (GO:0030544)Hsp70 protein binding (GO:0030544)cytoplasm (GO:0005737)metal ion binding (GO:0046872)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)positive regulation of gene expression (GO:0010628)positive regulation of membrane repolarization during cardiac muscle cell action potential (GO:1905033)positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (GO:1905026)positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (GO:1905026)positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential (GO:1905026)protein binding (GO:0005515)protein-folding chaperone binding (GO:0051087)regulation of cardiac muscle contraction (GO:0055117)regulation of cardiac muscle contraction (GO:0055117)regulation of heart looping (GO:1901207)regulation of heart looping (GO:1901207)transmembrane transporter binding (GO:0044325)transmembrane transporter binding (GO:0044325)zinc ion binding (GO:0008270)
Expression (TPM)
RNF207 — as a Regulated Gene

TFs regulating RNF207 0 TFs

Transcription factors with Perturb-seq knockdown data for RNF207. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF207 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RNF207

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF207, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:5,980,417–5,980,986 225.5 kb Distal (>10kb) Multiome 282
chr1:5,991,687–5,993,712 213.5 kb Distal (>10kb) Multiome 829
chr1:6,127,538–6,128,516 78.2 kb Distal (>10kb) Multiome 300
chr1:6,148,503–6,149,108 57.3 kb Distal (>10kb) Multiome 254
chr1:6,199,148–6,200,364 6.4 kb Proximal (<10kb) Multiome 992
chr1:6,204,893–6,206,690 873 bp At TSS Multiome 913
chr1:6,208,737–6,209,635 3.3 kb Proximal (<10kb) Multiome 362
chr1:6,235,160–6,236,710 29.9 kb Distal (>10kb) Multiome 673
chr1:6,241,773–6,242,771 36.1 kb Distal (>10kb) Multiome 241
chr1:6,244,532–6,247,144 39.9 kb Distal (>10kb) Multiome 1073
chr1:6,248,779–6,250,153 43.4 kb Distal (>10kb) Multiome 287
chr1:6,259,688–6,261,954 54.0 kb Distal (>10kb) Multiome 550
chr1:6,392,724–6,394,325 187.5 kb Distal (>10kb) Multiome 819
chr1:6,418,998–6,420,339 213.7 kb Distal (>10kb) Multiome 335
chr1:6,440,165–6,441,114 234.5 kb Distal (>10kb) Multiome 215
chr1:6,446,981–6,449,427 241.8 kb Distal (>10kb) Multiome 665
chr1:6,455,053–6,455,773 249.2 kb Distal (>10kb) Multiome 105
chr1:6,470,716–6,471,189 264.8 kb Distal (>10kb) Multiome 148
chr1:6,471,308–6,471,972 265.5 kb Distal (>10kb) Multiome 192
chr1:6,486,194–6,486,953 280.5 kb Distal (>10kb) Multiome 416
chr1:6,489,772–6,491,050 284.5 kb Distal (>10kb) Multiome 676
chr1:6,497,162–6,497,841 291.4 kb Distal (>10kb) Multiome 324

Genome Browser

Genomic view of the RNF207 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:5,970,417 – 6,507,841
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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