Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF144B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF144B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF144B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:18,122,030–18,123,058 | 264.9 kb | Distal (>10kb) Multiome | 824 | |
| chr6:18,154,608–18,156,434 | 232.2 kb | Distal (>10kb) Multiome | 937 | |
| chr6:18,185,739–18,186,332 | 201.4 kb | Distal (>10kb) Multiome | 189 | |
| chr6:18,263,804–18,265,203 | 123.0 kb | Distal (>10kb) Multiome | 869 | |
| chr6:18,386,971–18,387,968 | 143 bp | At TSS Multiome | 780 | |
| chr6:18,394,997–18,395,808 | 7.9 kb | Proximal (<10kb) Multiome | 134 |
Genomic view of the RNF144B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.