The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF141. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF141 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF141, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:10,293,485–10,294,954 | 247.1 kb | Distal (>10kb) Multiome | 728 | |
| chr11:10,303,927–10,306,992 | 236.3 kb | Distal (>10kb) Multiome | 897 | |
| chr11:10,307,252–10,308,323 | 233.2 kb | Distal (>10kb) Multiome | 800 | |
| chr11:10,309,037–10,310,838 | 231.5 kb | Distal (>10kb) Multiome | 494 | |
| chr11:10,351,409–10,352,676 | 189.2 kb | Distal (>10kb) Multiome | 677 | |
| chr11:10,450,400–10,451,424 | 90.1 kb | Distal (>10kb) Multiome | 419 | |
| chr11:10,455,858–10,456,376 | 85.2 kb | Distal (>10kb) Multiome | 394 | |
| chr11:10,540,488–10,541,619 | 25 bp | At TSS Multiome | 859 | |
| chr11:10,735,514–10,736,088 | 194.7 kb | Distal (>10kb) Multiome | 637 | |
| chr11:10,750,622–10,751,770 | 209.9 kb | Distal (>10kb) Multiome | 974 | |
| chr11:10,792,316–10,792,962 | 251.5 kb | Distal (>10kb) Multiome | 530 | |
| chr11:10,807,818–10,809,752 | 267.9 kb | Distal (>10kb) Multiome | 1038 |
Genomic view of the RNF141 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.