The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF135. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF135 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF135, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:30,707,918–30,709,425 | 262.4 kb | Distal (>10kb) Multiome | 471 | |
| chr17:30,731,337–30,732,077 | 239.4 kb | Distal (>10kb) Multiome | 352 | |
| chr17:30,824,074–30,825,310 | 146.3 kb | Distal (>10kb) Multiome | 868 | |
| chr17:30,831,761–30,832,403 | 139.0 kb | Distal (>10kb) Multiome | 803 | |
| chr17:30,906,142–30,906,858 | 64.6 kb | Distal (>10kb) Multiome | 1033 | |
| chr17:30,921,825–30,922,307 | 48.9 kb | Distal (>10kb) Multiome | 262 | |
| chr17:30,970,349–30,970,624 | 397 bp | At TSS | 145 | |
| chr17:30,970,780–30,971,531 | 95 bp | At TSS Multiome | 537 | |
| chr17:31,008,384–31,008,968 | 37.6 kb | Distal (>10kb) Multiome | 415 | |
| chr17:31,094,330–31,095,946 | 123.8 kb | Distal (>10kb) Multiome | 759 |
Genomic view of the RNF135 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.