The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for RNF122. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF122 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF122, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:33,471,825–33,473,740 | 93.9 kb | Distal (>10kb) Multiome | 999 | |
| chr8:33,484,346–33,485,645 | 82.1 kb | Distal (>10kb) Multiome | 940 | |
| chr8:33,512,345–33,515,139 | 52.4 kb | Distal (>10kb) Multiome | 1310 | |
| chr8:33,543,087–33,543,854 | 23.7 kb | Distal (>10kb) Multiome | 102 | |
| chr8:33,563,606–33,564,473 | 2.7 kb | Proximal (<10kb) | 89 | |
| chr8:33,564,991–33,565,345 | 1.8 kb | Proximal (<10kb) | 166 | |
| chr8:33,566,077–33,567,716 | 12 bp | At TSS Multiome | 711 | |
| chr8:33,626,086–33,627,037 | 59.3 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the RNF122 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.