The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for RNF103. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF103 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF103, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:86,336,997–86,338,159 | 286.3 kb | Distal (>10kb) Multiome | 267 | |
| chr2:86,368,200–86,368,804 | 255.4 kb | Distal (>10kb) Multiome | 227 | |
| chr2:86,440,468–86,442,936 | 182.7 kb | Distal (>10kb) Multiome | 1229 | |
| chr2:86,562,703–86,563,941 | 60.6 kb | Distal (>10kb) Multiome | 1017 | |
| chr2:86,622,458–86,624,092 | 99 bp | At TSS Multiome | 913 | |
| chr2:86,719,886–86,720,543 | 96.3 kb | Distal (>10kb) Multiome | 245 | |
| chr2:86,785,940–86,786,595 | 162.4 kb | Distal (>10kb) Multiome | 161 | |
| chr2:86,807,228–86,809,045 | 183.9 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the RNF103 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.