This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RND2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RND2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RND2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,744,352–42,745,375 | 280.3 kb | Distal (>10kb) Multiome | 966 | |
| chr17:42,761,003–42,761,468 | 264.2 kb | Distal (>10kb) Multiome | 335 | |
| chr17:42,780,029–42,780,899 | 244.7 kb | Distal (>10kb) Multiome | 712 | |
| chr17:42,798,408–42,798,877 | 226.5 kb | Distal (>10kb) Multiome | 866 | |
| chr17:42,823,968–42,824,503 | 200.9 kb | Distal (>10kb) Multiome | 829 | |
| chr17:42,832,889–42,833,841 | 191.9 kb | Distal (>10kb) Multiome | 980 | |
| chr17:42,964,237–42,964,843 | 60.7 kb | Distal (>10kb) Multiome | 655 | |
| chr17:42,979,966–42,981,044 | 44.8 kb | Distal (>10kb) Multiome | 843 | |
| chr17:42,997,598–42,998,917 | 26.9 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:43,021,026–43,022,568 | 2.9 kb | Proximal (<10kb) Multiome | 973 | |
| chr17:43,024,255–43,025,752 | 220 bp | At TSS Multiome | 811 | |
| chr17:43,124,981–43,125,702 | 100.2 kb | Distal (>10kb) Multiome | 837 | |
| chr17:43,169,744–43,171,576 | 145.9 kb | Distal (>10kb) Multiome | 1018 | |
| chr17:43,211,494–43,212,392 | 186.7 kb | Distal (>10kb) Multiome HiCAR | 586 |
Genomic view of the RND2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.