This locus represents naturally occurring read-through transcription between the neighboring RNASEK (ribonuclease, RNase K) and C17orf49 (chromosome 17 open reading frame 49) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is unlikely to produce a protein product. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for RNASEK-C17orf49. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNASEK-C17orf49 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNASEK-C17orf49, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,012,245–7,012,890 | at TSS | At TSS | 804 | |
| chr17:7,014,335–7,015,213 | 1.7 kb | Proximal (<10kb) | 842 | |
| chr17:7,019,807–7,020,192 | 7.2 kb | Proximal (<10kb) | 234 | |
| chr17:7,021,831–7,024,265 | 9.2 kb | Proximal (<10kb) | 614 |
Genomic view of the RNASEK-C17orf49 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.