RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]
Transcription factors with Perturb-seq knockdown data for RMI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:11,032,660–11,033,355 | 279.8 kb | Distal (>10kb) Multiome | 81 | |
| chr16:11,104,839–11,105,431 | 207.8 kb | Distal (>10kb) Multiome | 471 | |
| chr16:11,254,519–11,257,585 | 56.8 kb | Distal (>10kb) Multiome | 1111 | |
| chr16:11,306,227–11,307,080 | 5.8 kb | Proximal (<10kb) | 197 | |
| chr16:11,315,468–11,315,998 | 2.8 kb | Proximal (<10kb) Multiome | 240 | |
| chr16:11,328,368–11,329,056 | 15.8 kb | Distal (>10kb) Multiome | 405 | |
| chr16:11,344,993–11,345,929 | 32.5 kb | Distal (>10kb) Multiome | 820 | |
| chr16:11,586,675–11,587,433 | 274.2 kb | Distal (>10kb) Multiome | 663 |
Genomic view of the RMI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.