Enables microtubule binding activity. Involved in intracellular calcium ion homeostasis. Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RMDN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMDN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMDN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,470,654–40,471,315 | 284.3 kb | Distal (>10kb) Multiome | 463 | |
| chr15:40,511,458–40,512,083 | 243.5 kb | Distal (>10kb) Multiome | 646 | |
| chr15:40,593,777–40,594,776 | 161.1 kb | Distal (>10kb) Multiome | 899 | |
| chr15:40,694,639–40,695,262 | 60.2 kb | Distal (>10kb) Multiome | 831 | |
| chr15:40,754,834–40,755,729 | 74 bp | At TSS Multiome | 816 | |
| chr15:40,763,848–40,764,563 | 8.9 kb | Proximal (<10kb) Multiome | 799 | |
| chr15:40,806,990–40,807,956 | 52.3 kb | Distal (>10kb) Multiome | 782 | |
| chr15:40,843,756–40,844,502 | 88.9 kb | Distal (>10kb) Multiome | 364 | |
| chr15:40,873,588–40,874,396 | 118.7 kb | Distal (>10kb) Multiome | 556 | |
| chr15:40,893,927–40,894,547 | 139.1 kb | Distal (>10kb) Multiome | 741 | |
| chr15:40,906,419–40,906,902 | 151.3 kb | Distal (>10kb) Multiome | 630 | |
| chr15:40,941,651–40,942,174 | 186.7 kb | Distal (>10kb) Multiome | 643 | |
| chr15:40,952,899–40,953,683 | 198.1 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the RMDN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.