This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for RMC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:23,259,654–23,260,831 | 243.3 kb | Distal (>10kb) Multiome | 655 | |
| chr18:23,437,346–23,438,074 | 65.7 kb | Distal (>10kb) Multiome | 628 | |
| chr18:23,452,793–23,453,775 | 50.3 kb | Distal (>10kb) Multiome | 796 | |
| chr18:23,498,907–23,499,080 | 4.4 kb | Proximal (<10kb) | 167 | |
| chr18:23,502,975–23,503,998 | 123 bp | At TSS Multiome | 907 | |
| chr18:23,505,435–23,505,815 | 1.9 kb | Proximal (<10kb) | 174 | |
| chr18:23,586,020–23,587,174 | 83.2 kb | Distal (>10kb) Multiome | 908 | |
| chr18:23,609,370–23,609,991 | 106.2 kb | Distal (>10kb) Multiome | 79 | |
| chr18:23,618,918–23,619,643 | 115.8 kb | Distal (>10kb) Multiome | 295 | |
| chr18:23,662,307–23,663,058 | 159.2 kb | Distal (>10kb) Multiome | 349 | |
| chr18:23,689,205–23,690,311 | 186.0 kb | Distal (>10kb) Multiome | 469 | |
| chr18:23,721,611–23,722,408 | 218.5 kb | Distal (>10kb) Multiome | 82 |
Genomic view of the RMC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.