The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RIPK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIPK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIPK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:41,506,872–41,508,775 | 258.8 kb | Distal (>10kb) Multiome | 270 | |
| chr21:41,678,592–41,679,284 | 88.0 kb | Distal (>10kb) Multiome | 586 | |
| chr21:41,762,412–41,762,643 | 4.4 kb | Proximal (<10kb) | 144 | |
| chr21:41,766,154–41,767,269 | 24 bp | At TSS Multiome | 579 | |
| chr21:41,778,087–41,778,564 | 11.2 kb | Distal (>10kb) Multiome | 367 | |
| chr21:41,878,502–41,879,847 | 112.1 kb | Distal (>10kb) Multiome | 630 | |
| chr21:41,953,094–41,954,549 | 187.0 kb | Distal (>10kb) Multiome | 667 | |
| chr21:42,009,116–42,011,396 | 243.2 kb | Distal (>10kb) Multiome | 954 |
Genomic view of the RIPK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.