RIOX1
ribosomal oxygenase 1 | FLJ21802, JMJD9, MAPJD, NO66, C14orf169

Enables peptidyl-histidine dioxygenase activity and protein demethylase activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of osteoblast differentiation; and regulation of DNA repair. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-1
Biological processes 32 terms
2-oxoglutarate-dependent dioxygenase activity (GO:0016706)2-oxoglutarate-dependent dioxygenase activity (GO:0016706)2-oxoglutarate-dependent dioxygenase activity (GO:0016706)chromatin remodeling (GO:0006338)histone H3K36 demethylase activity (GO:0051864)histone H3K36 demethylase activity (GO:0051864)histone H3K36 demethylase activity (GO:0051864)histone H3K36me/H3K36me2 demethylase activity (GO:0140680)histone H3K4 demethylase activity (GO:0032453)histone H3K4me/H3K4me2/H3K4me3 demethylase activity (GO:0034647)histone H3K4me/H3K4me2/H3K4me3 demethylase activity (GO:0034647)iron ion binding (GO:0005506)iron ion binding (GO:0005506)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of osteoblast differentiation (GO:0045668)negative regulation of osteoblast differentiation (GO:0045668)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-histidine dioxygenase activity (GO:0036139)peptidyl-histidine dioxygenase activity (GO:0036139)peptidyl-histidine dioxygenase activity (GO:0036139)protein binding (GO:0005515)protein demethylase activity (GO:0140457)protein demethylase activity (GO:0140457)protein hydroxylation (GO:0018126)regulation of DNA repair (GO:0006282)
Expression (TPM)
RIOX1 — as a Regulated Gene

TFs regulating RIOX1 0 TFs

Transcription factors with Perturb-seq knockdown data for RIOX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIOX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RIOX1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIOX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:73,237,315–73,238,355 253.1 kb Distal (>10kb) Multiome 296
chr14:73,457,486–73,459,145 32.3 kb Distal (>10kb) Multiome 720
chr14:73,490,604–73,491,982 50 bp At TSS Multiome 866
chr14:73,569,145–73,570,199 78.5 kb Distal (>10kb) Multiome 680
chr14:73,591,810–73,592,493 101.2 kb Distal (>10kb) Multiome 259
chr14:73,612,266–73,613,237 121.7 kb Distal (>10kb) Multiome 521
chr14:73,633,521–73,634,788 143.5 kb Distal (>10kb) Multiome 541
chr14:73,644,535–73,645,291 154.0 kb Distal (>10kb) Multiome 667
chr14:73,713,545–73,714,769 223.3 kb Distal (>10kb) Multiome 759
chr14:73,718,770–73,719,334 228.2 kb Distal (>10kb) Multiome 138
chr14:73,759,247–73,760,633 269.4 kb Distal (>10kb) Multiome 912
chr14:73,771,644–73,772,269 281.0 kb Distal (>10kb) Multiome 846
chr14:73,786,685–73,787,517 296.2 kb Distal (>10kb) Multiome 497

Genome Browser

Genomic view of the RIOX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:73,227,315 – 73,797,517
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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