This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast cancer in human patients. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for RINT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RINT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RINT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:105,350,605–105,351,448 | 181.1 kb | Distal (>10kb) Multiome | 116 | |
| chr7:105,387,785–105,389,508 | 143.2 kb | Distal (>10kb) Multiome | 725 | |
| chr7:105,521,330–105,522,854 | 10.0 kb | Distal (>10kb) Multiome | 900 | |
| chr7:105,531,803–105,532,700 | 9 bp | At TSS Multiome | 946 | |
| chr7:105,580,977–105,581,814 | 49.3 kb | Distal (>10kb) Multiome | 492 | |
| chr7:105,638,494–105,639,567 | 107.1 kb | Distal (>10kb) Multiome | 209 | |
| chr7:105,643,274–105,643,732 | 111.4 kb | Distal (>10kb) Multiome | 211 | |
| chr7:105,651,976–105,652,948 | 120.4 kb | Distal (>10kb) Multiome | 292 | |
| chr7:105,655,354–105,656,152 | 123.5 kb | Distal (>10kb) Multiome | 203 | |
| chr7:105,657,015–105,657,727 | 125.1 kb | Distal (>10kb) Multiome | 205 | |
| chr7:105,664,641–105,665,449 | 132.9 kb | Distal (>10kb) Multiome | 422 | |
| chr7:105,689,008–105,690,124 | 157.2 kb | Distal (>10kb) Multiome | 195 | |
| chr7:105,695,816–105,698,274 | 165.1 kb | Distal (>10kb) Multiome | 292 |
Genomic view of the RINT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.