RILP

Rab interacting lysosomal protein | FLJ31193

This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]

Biological processes 33 terms

cholesterol homeostasis (GO:0042632)ciliary basal body (GO:0036064)cilium assembly (GO:0060271)cytoplasm (GO:0005737)dynein light intermediate chain binding (GO:0051959)dynein light intermediate chain binding (GO:0051959)early endosome to late endosome transport (GO:0045022)early endosome to late endosome transport (GO:0045022)endosome membrane (GO:0010008)endosome to lysosome transport (GO:0008333)endosome transport via multivesicular body sorting pathway (GO:0032509)intralumenal vesicle formation (GO:0070676)late endosome (GO:0005770)late endosome (GO:0005770)late endosome membrane (GO:0031902)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosome (GO:0005764)lysosome (GO:0005764)lysosome to ER cholesterol transport (GO:0090120)negative regulation of protein catabolic process (GO:0042177)phagocytic vesicle membrane (GO:0030670)positive regulation of protein catabolic process (GO:0045732)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein transport (GO:0015031)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)sterol sensor activity (GO:0032935)

Expression (TPM)

TFs regulating RILP 0 TFs

Transcription factors with Perturb-seq knockdown data for RILP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RILP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RILP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RILP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:1,268,002–1,268,635	380.8 kb	Distal (>10kb) Multiome HiCAR	644
chr17:1,399,339–1,400,718	248.8 kb	Distal (>10kb) Multiome	879
chr17:1,455,335–1,456,916	192.7 kb	Distal (>10kb) Multiome	879
chr17:1,484,963–1,486,119	163.8 kb	Distal (>10kb) Multiome HiCAR	562
chr17:1,487,906–1,488,733	160.8 kb	Distal (>10kb) Multiome HiCAR	597
chr17:1,490,717–1,492,156	157.7 kb	Distal (>10kb) Multiome	675
chr17:1,515,722–1,517,330	132.3 kb	Distal (>10kb) Multiome	796
chr17:1,562,314–1,563,047	86.2 kb	Distal (>10kb) Multiome HiCAR	685
chr17:1,627,811–1,629,617	20.3 kb	Distal (>10kb) Multiome	753
chr17:1,642,697–1,644,482	5.8 kb	Proximal (<10kb) Multiome	467
chr17:1,648,163–1,650,244	54 bp	At TSS Multiome	932
chr17:1,684,343–1,685,342	35.9 kb	Distal (>10kb) Multiome	728
chr17:1,710,017–1,710,765	61.4 kb	Distal (>10kb) Multiome	500
chr17:1,713,886–1,717,908	68.4 kb	Distal (>10kb) Multiome	1042
chr17:1,724,373–1,725,206	75.6 kb	Distal (>10kb) Multiome	720
chr17:1,829,368–1,830,287	180.8 kb	Distal (>10kb) Multiome	660
chr17:1,908,573–1,908,999	259.6 kb	Distal (>10kb) Multiome	239

Genome Browser

Genomic view of the RILP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.