RHOT2

ras homolog family member T2 | MIRO-2, MIRO2, ARHT2, C16orf39

This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]

Member of: DE-6 DE-6.17

Biological processes 27 terms

ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)GDP binding (GO:0019003)GDP binding (GO:0019003)GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)calcium ion binding (GO:0005509)cellular homeostasis (GO:0019725)magnesium ion binding (GO:0000287)magnesium ion binding (GO:0000287)membrane (GO:0016020)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane permeabilization (GO:0097345)mitochondrial outer membrane permeabilization (GO:0097345)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)mitochondrion transport along microtubule (GO:0047497)mitochondrion transport along microtubule (GO:0047497)mitochondrion transport along microtubule (GO:0047497)protein binding (GO:0005515)

Expression (TPM)

TFs regulating RHOT2 0 TFs

Transcription factors with Perturb-seq knockdown data for RHOT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RHOT2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:378,999–379,813	288.7 kb	Distal (>10kb) Multiome	225
chr16:380,836–382,614	286.1 kb	Distal (>10kb) Multiome	634
chr16:383,438–384,218	284.3 kb	Distal (>10kb) Multiome	342
chr16:396,893–397,640	270.6 kb	Distal (>10kb) Multiome	496
chr16:401,380–402,199	266.2 kb	Distal (>10kb) Multiome	818
chr16:424,888–426,136	242.5 kb	Distal (>10kb) Multiome	752
chr16:483,333–484,000	184.4 kb	Distal (>10kb) Multiome	143
chr16:526,749–528,601	140.5 kb	Distal (>10kb) Multiome	811
chr16:569,530–570,338	98.3 kb	Distal (>10kb) Multiome	492
chr16:578,896–579,353	89.0 kb	Distal (>10kb) Multiome	511
chr16:588,593–590,724	78.2 kb	Distal (>10kb) Multiome	853
chr16:635,900–638,127	31.7 kb	Distal (>10kb) Multiome	1021
chr16:641,491–643,007	26.2 kb	Distal (>10kb) Multiome	856
chr16:648,795–649,829	18.8 kb	Distal (>10kb) Multiome	862
chr16:660,457–661,656	7.2 kb	Proximal (<10kb) Multiome	456
chr16:667,633–668,442	77 bp	At TSS Multiome	838
chr16:678,847–681,585	11.9 kb	Distal (>10kb) Multiome	803
chr16:683,618–684,859	16.3 kb	Distal (>10kb) Multiome	701
chr16:694,897–695,485	27.3 kb	Distal (>10kb) Multiome	390
chr16:705,242–706,468	37.9 kb	Distal (>10kb) Multiome	248
chr16:714,577–716,048	47.0 kb	Distal (>10kb) Multiome	555
chr16:720,434–721,963	53.3 kb	Distal (>10kb) Multiome	966
chr16:726,310–729,144	58.9 kb	Distal (>10kb) Multiome	736
chr16:740,359–741,596	73.0 kb	Distal (>10kb) Multiome	897
chr16:787,564–789,160	120.4 kb	Distal (>10kb) Multiome	635
chr16:807,352–808,044	139.7 kb	Distal (>10kb) Multiome	600
chr16:813,330–813,960	145.7 kb	Distal (>10kb) Multiome	325

Genome Browser

Genomic view of the RHOT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.