This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for RHOG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:3,580,829–3,581,470 | 259.7 kb | Distal (>10kb) Multiome | 80 | |
| chr11:3,614,331–3,614,934 | 226.4 kb | Distal (>10kb) Multiome | 150 | |
| chr11:3,641,420–3,643,023 | 198.8 kb | Distal (>10kb) Multiome | 679 | |
| chr11:3,796,972–3,798,333 | 43.2 kb | Distal (>10kb) Multiome | 985 | |
| chr11:3,807,708–3,808,953 | 32.6 kb | Distal (>10kb) Multiome | 598 | |
| chr11:3,824,581–3,825,191 | 16.1 kb | Distal (>10kb) Multiome | 332 | |
| chr11:3,840,339–3,841,901 | 121 bp | At TSS Multiome | 853 | |
| chr11:3,854,400–3,856,473 | 14.2 kb | Distal (>10kb) Multiome | 929 | |
| chr11:4,094,080–4,095,334 | 253.8 kb | Distal (>10kb) Multiome HiCAR | 925 |
Genomic view of the RHOG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.