Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for RHOD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,842,896–66,843,952 | 213.4 kb | Distal (>10kb) Multiome | 843 | |
| chr11:66,855,758–66,857,980 | 200.5 kb | Distal (>10kb) Multiome | 795 | |
| chr11:66,882,995–66,883,462 | 173.6 kb | Distal (>10kb) Multiome | 277 | |
| chr11:66,957,708–66,959,038 | 98.3 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,023,002–67,023,688 | 33.4 kb | Distal (>10kb) Multiome | 243 | |
| chr11:67,053,949–67,054,109 | 2.7 kb | Proximal (<10kb) | 235 | |
| chr11:67,056,596–67,057,312 | 40 bp | At TSS Multiome | 382 | |
| chr11:67,071,470–67,071,999 | 15.0 kb | Distal (>10kb) Multiome | 302 | |
| chr11:67,117,553–67,120,314 | 62.2 kb | Distal (>10kb) Multiome | 762 | |
| chr11:67,239,493–67,240,241 | 183.1 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 209.6 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 232.3 kb | Distal (>10kb) Multiome HiCAR | 985 | |
| chr11:67,302,488–67,304,170 | 246.6 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 260.9 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,352,967–67,354,228 | 296.8 kb | Distal (>10kb) Multiome | 781 |
Genomic view of the RHOD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.