The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for RHOBTB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOBTB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOBTB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,864,299–22,865,847 | 134.9 kb | Distal (>10kb) Multiome | 507 | |
| chr8:22,998,974–23,000,300 | 359 bp | At TSS Multiome | 597 | |
| chr8:23,004,667–23,004,832 | 5.1 kb | Proximal (<10kb) | 58 | |
| chr8:23,008,685–23,009,096 | 9.1 kb | Proximal (<10kb) | 85 | |
| chr8:23,019,069–23,020,109 | 19.5 kb | Distal (>10kb) Multiome | 452 | |
| chr8:23,049,698–23,050,409 | 50.1 kb | Distal (>10kb) Multiome | 277 | |
| chr8:23,068,457–23,069,444 | 69.1 kb | Distal (>10kb) Multiome | 856 | |
| chr8:23,083,702–23,084,469 | 84.4 kb | Distal (>10kb) Multiome | 538 | |
| chr8:23,162,920–23,164,386 | 164.0 kb | Distal (>10kb) Multiome | 808 | |
| chr8:23,224,394–23,225,450 | 225.1 kb | Distal (>10kb) Multiome | 678 | |
| chr8:23,246,206–23,247,324 | 246.7 kb | Distal (>10kb) Multiome | 941 | |
| chr8:23,287,908–23,288,715 | 288.2 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the RHOBTB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.