Enables serine-type endopeptidase activity. Involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RHBDD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHBDD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHBDD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:226,649,671–226,650,681 | 185.7 kb | Distal (>10kb) Multiome | 758 | |
| chr2:226,720,273–226,721,822 | 115.0 kb | Distal (>10kb) Multiome | 136 | |
| chr2:226,790,932–226,792,958 | 44.3 kb | Distal (>10kb) Multiome | 707 | |
| chr2:226,797,838–226,801,976 | 34.8 kb | Distal (>10kb) Multiome | 1020 | |
| chr2:226,835,365–226,836,725 | 47 bp | At TSS Multiome | 964 | |
| chr2:226,874,251–226,875,681 | 38.8 kb | Distal (>10kb) Multiome | 292 |
Genomic view of the RHBDD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.