This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for RGS9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:64,836,863–64,837,361 | 263.7 kb | Distal (>10kb) Multiome | 286 | |
| chr17:64,918,788–64,920,342 | 181.3 kb | Distal (>10kb) Multiome | 704 | |
| chr17:64,975,096–64,976,234 | 125.2 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:65,055,840–65,057,373 | 44.0 kb | Distal (>10kb) Multiome | 946 | |
| chr17:65,057,526–65,058,894 | 42.4 kb | Distal (>10kb) Multiome | 300 | |
| chr17:65,100,219–65,101,279 | 66 bp | At TSS Multiome | 634 | |
| chr17:65,123,077–65,123,614 | 22.6 kb | Distal (>10kb) Multiome | 724 | |
| chr17:65,136,968–65,137,867 | 36.5 kb | Distal (>10kb) Multiome | 573 | |
| chr17:65,294,030–65,294,715 | 193.6 kb | Distal (>10kb) Multiome | 350 |
Genomic view of the RGS9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.