The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for RGS20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:52,713,424–52,715,199 | 1165.4 kb | Distal (>10kb) Multiome HiCAR | 913 | |
| chr8:53,656,485–53,658,965 | 222.1 kb | Distal (>10kb) Multiome | 536 | |
| chr8:53,692,724–53,693,521 | 186.8 kb | Distal (>10kb) Multiome | 302 | |
| chr8:53,766,492–53,767,096 | 113.2 kb | Distal (>10kb) Multiome | 118 | |
| chr8:53,842,551–53,843,618 | 36.8 kb | Distal (>10kb) Multiome | 936 | |
| chr8:53,876,659–53,878,094 | 1.9 kb | Proximal (<10kb) | 479 | |
| chr8:53,879,185–53,882,655 | 11 bp | At TSS Multiome | 721 | |
| chr8:53,885,464–53,885,634 | 5.5 kb | Proximal (<10kb) | 102 | |
| chr8:54,021,584–54,023,157 | 142.4 kb | Distal (>10kb) Multiome | 965 | |
| chr8:54,101,305–54,102,633 | 222.0 kb | Distal (>10kb) Multiome | 744 | |
| chr8:54,134,624–54,135,508 | 255.2 kb | Distal (>10kb) Multiome HiCAR | 807 | |
| chr8:54,457,494–54,460,098 | 579.6 kb | Distal (>10kb) Multiome HiCAR | 361 | |
| chr8:54,466,222–54,467,657 | 586.8 kb | Distal (>10kb) Multiome HiCAR | 244 |
Genomic view of the RGS20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.