Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Located in cytosol and plasma membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RGP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:35,489,223–35,490,919 | 259.3 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,603,584–35,606,173 | 145.1 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,645,821–35,647,298 | 103.4 kb | Distal (>10kb) Multiome | 734 | |
| chr9:35,657,275–35,659,114 | 91.2 kb | Distal (>10kb) Multiome | 1156 | |
| chr9:35,664,903–35,665,580 | 84.0 kb | Distal (>10kb) Multiome | 814 | |
| chr9:35,675,371–35,676,451 | 73.3 kb | Distal (>10kb) Multiome | 223 | |
| chr9:35,689,224–35,691,525 | 58.1 kb | Distal (>10kb) Multiome | 541 | |
| chr9:35,731,682–35,733,531 | 16.9 kb | Distal (>10kb) Multiome | 920 | |
| chr9:35,748,884–35,750,005 | 10 bp | At TSS Multiome | 667 | |
| chr9:35,756,620–35,757,642 | 7.8 kb | Proximal (<10kb) Multiome | 810 | |
| chr9:35,790,361–35,791,220 | 41.3 kb | Distal (>10kb) Multiome | 282 | |
| chr9:35,791,337–35,791,986 | 42.5 kb | Distal (>10kb) Multiome | 98 | |
| chr9:35,811,906–35,812,486 | 62.9 kb | Distal (>10kb) Multiome | 610 | |
| chr9:35,814,402–35,815,681 | 66.0 kb | Distal (>10kb) Multiome | 896 | |
| chr9:35,828,657–35,829,781 | 80.0 kb | Distal (>10kb) Multiome | 419 | |
| chr9:35,845,853–35,846,711 | 97.0 kb | Distal (>10kb) Multiome | 141 | |
| chr9:36,036,454–36,037,604 | 287.7 kb | Distal (>10kb) Multiome | 528 |
Genomic view of the RGP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.