Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for REXO5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REXO5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REXO5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:20,675,760–20,676,308 | 130.4 kb | Distal (>10kb) Multiome | 243 | |
| chr16:20,740,958–20,742,211 | 64.8 kb | Distal (>10kb) Multiome | 971 | |
| chr16:20,806,106–20,807,318 | 36 bp | At TSS Multiome | 1078 | |
| chr16:20,899,731–20,901,323 | 94.1 kb | Distal (>10kb) Multiome | 1027 |
Genomic view of the REXO5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.