Enables DNA binding activity and nuclease activity. Involved in DNA catabolic process and DNA repair. Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for REXO4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REXO4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REXO4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:133,120,589–133,121,652 | 296.7 kb | Distal (>10kb) Multiome | 599 | |
| chr9:133,144,161–133,144,920 | 273.4 kb | Distal (>10kb) Multiome | 776 | |
| chr9:133,147,412–133,149,938 | 268.6 kb | Distal (>10kb) Multiome | 979 | |
| chr9:133,163,575–133,164,128 | 254.1 kb | Distal (>10kb) Multiome | 308 | |
| chr9:133,238,117–133,239,420 | 179.4 kb | Distal (>10kb) Multiome | 620 | |
| chr9:133,335,737–133,336,702 | 81.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr9:133,347,434–133,348,830 | 69.9 kb | Distal (>10kb) Multiome | 893 | |
| chr9:133,356,029–133,357,223 | 61.4 kb | Distal (>10kb) Multiome | 648 | |
| chr9:133,375,394–133,376,740 | 41.8 kb | Distal (>10kb) Multiome | 834 | |
| chr9:133,417,747–133,418,516 | 120 bp | At TSS Multiome | 1015 | |
| chr9:133,428,444–133,429,113 | 10.7 kb | Distal (>10kb) Multiome | 255 | |
| chr9:133,429,621–133,430,196 | 11.9 kb | Distal (>10kb) Multiome | 197 | |
| chr9:133,458,883–133,460,984 | 41.9 kb | Distal (>10kb) Multiome | 835 | |
| chr9:133,478,485–133,479,696 | 61.2 kb | Distal (>10kb) Multiome | 653 | |
| chr9:133,534,455–133,535,168 | 116.7 kb | Distal (>10kb) Multiome | 295 | |
| chr9:133,608,924–133,609,730 | 191.4 kb | Distal (>10kb) Multiome | 411 |
Genomic view of the REXO4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.