The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for RER1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RER1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RER1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:2,132,340–2,134,100 | 258.4 kb | Distal (>10kb) Multiome | 508 | |
| chr1:2,189,382–2,190,314 | 202.1 kb | Distal (>10kb) Multiome HiCAR | 719 | |
| chr1:2,194,502–2,195,788 | 196.8 kb | Distal (>10kb) Multiome HiCAR | 789 | |
| chr1:2,199,148–2,199,756 | 192.4 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr1:2,204,191–2,206,396 | 186.7 kb | Distal (>10kb) Multiome HiCAR | 597 | |
| chr1:2,212,255–2,213,305 | 179.1 kb | Distal (>10kb) Multiome | 601 | |
| chr1:2,226,557–2,228,163 | 164.0 kb | Distal (>10kb) Multiome | 675 | |
| chr1:2,248,086–2,248,655 | 143.4 kb | Distal (>10kb) Multiome | 296 | |
| chr1:2,279,142–2,279,636 | 112.4 kb | Distal (>10kb) Multiome | 172 | |
| chr1:2,311,328–2,311,918 | 80.2 kb | Distal (>10kb) Multiome | 366 | |
| chr1:2,314,340–2,315,728 | 76.8 kb | Distal (>10kb) Multiome | 557 | |
| chr1:2,381,779–2,382,023 | 9.8 kb | Proximal (<10kb) | 375 | |
| chr1:2,391,076–2,392,400 | 140 bp | At TSS Multiome | 820 | |
| chr1:2,411,953–2,414,836 | 20.8 kb | Distal (>10kb) Multiome | 918 | |
| chr1:2,525,908–2,527,142 | 134.6 kb | Distal (>10kb) Multiome | 668 | |
| chr1:2,529,108–2,529,820 | 137.5 kb | Distal (>10kb) Multiome | 222 | |
| chr1:2,545,676–2,548,580 | 156.5 kb | Distal (>10kb) Multiome | 918 | |
| chr1:2,585,182–2,587,696 | 194.8 kb | Distal (>10kb) Multiome | 748 | |
| chr1:2,642,358–2,643,801 | 251.4 kb | Distal (>10kb) Multiome | 706 | |
| chr1:3,453,034–3,455,700 | 1061.4 kb | Distal (>10kb) Multiome HiCAR | 874 |
Genomic view of the RER1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.