The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for REPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:16,719,154–16,719,979 | 227.1 kb | Distal (>10kb) Multiome | 716 | |
| chrX:16,771,090–16,772,164 | 175.0 kb | Distal (>10kb) Multiome | 626 | |
| chrX:16,786,080–16,787,269 | 160.3 kb | Distal (>10kb) Multiome | 646 | |
| chrX:16,869,468–16,871,503 | 76.2 kb | Distal (>10kb) Multiome | 687 | |
| chrX:16,946,195–16,947,346 | 32 bp | At TSS Multiome | 329 | |
| chrX:17,007,183–17,007,806 | 60.8 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the REPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.