RENBP

renin binding protein | RBP, RNBP

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

Biological processes 17 terms

N-acetylneuraminate catabolic process (GO:0019262)N-acetylneuraminate catabolic process (GO:0019262)N-acylglucosamine 2-epimerase activity (GO:0050121)N-acylglucosamine 2-epimerase activity (GO:0050121)N-acylglucosamine 2-epimerase activity (GO:0050121)N-acylglucosamine 2-epimerase activity (GO:0050121)N-acylglucosamine 2-epimerase activity (GO:0050121)amino sugar metabolic process (GO:0006040)carbohydrate metabolic process (GO:0005975)cytosol (GO:0005829)endopeptidase inhibitor activity (GO:0004866)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)isomerase activity (GO:0016853)peptidase inhibitor activity (GO:0030414)protein binding (GO:0005515)regulation of blood pressure (GO:0008217)

Expression (TPM)

TFs regulating RENBP 0 TFs

Transcription factors with Perturb-seq knockdown data for RENBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RENBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RENBP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RENBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chrX:153,687,144–153,688,247	256.9 kb	Distal (>10kb) Multiome	201
chrX:153,723,829–153,725,285	220.0 kb	Distal (>10kb) Multiome	620
chrX:153,726,395–153,727,168	217.7 kb	Distal (>10kb) Multiome	529
chrX:153,793,808–153,795,045	150.2 kb	Distal (>10kb) Multiome	733
chrX:153,875,415–153,875,856	69.0 kb	Distal (>10kb) Multiome	847
chrX:153,878,887–153,879,684	65.4 kb	Distal (>10kb) Multiome	235
chrX:153,927,955–153,928,728	16.2 kb	Distal (>10kb) Multiome	711
chrX:153,934,763–153,935,658	9.5 kb	Proximal (<10kb) Multiome	446
chrX:153,947,417–153,947,594	5.4 kb	Proximal (<10kb)	390
chrX:154,097,040–154,098,161	153.2 kb	Distal (>10kb) Multiome	537
chrX:154,136,648–154,137,146	192.2 kb	Distal (>10kb) Multiome	391

Genome Browser

Genomic view of the RENBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.