This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RDM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RDM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RDM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:35,731,320–35,732,101 | 199.1 kb | Distal (>10kb) Multiome | 406 | |
| chr17:35,763,993–35,764,924 | 166.4 kb | Distal (>10kb) Multiome | 888 | |
| chr17:35,795,171–35,795,832 | 135.3 kb | Distal (>10kb) Multiome | 290 | |
| chr17:35,808,939–35,810,190 | 121.4 kb | Distal (>10kb) Multiome | 899 | |
| chr17:35,930,498–35,930,976 | 33 bp | At TSS Multiome | 353 | |
| chr17:35,942,380–35,943,327 | 12.1 kb | Distal (>10kb) Multiome | 169 | |
| chr17:36,182,854–36,183,349 | 252.4 kb | Distal (>10kb) Multiome | 128 | |
| chr17:36,482,565–36,483,505 | 552.3 kb | Distal (>10kb) Multiome HiCAR | 734 | |
| chr17:36,486,066–36,487,171 | 555.9 kb | Distal (>10kb) Multiome HiCAR | 719 |
Genomic view of the RDM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.