RDH11
retinol dehydrogenase 11 | ARSDR1, MDT1, SDR7C1

Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde and retinoid metabolic process. Acts upstream of or within retinal metabolic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 21 terms
11-cis-retinol dehydrogenase (NADP+) activity (GO:0102354)aldehyde dehydrogenase (NADP+) activity (GO:0033721)all-trans-retinol dehydrogenase (NAD+) activity (GO:0004745)all-trans-retinol dehydrogenase (NAD+) activity (GO:0004745)all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)cellular detoxification of aldehyde (GO:0110095)cellular detoxification of aldehyde (GO:0110095)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)photoreceptor inner segment (GO:0001917)protein binding (GO:0005515)retinal metabolic process (GO:0042574)retinoid metabolic process (GO:0001523)retinoid metabolic process (GO:0001523)retinol metabolic process (GO:0042572)retinol metabolic process (GO:0042572)visual perception (GO:0007601)
Expression (TPM)
RDH11 — as a Regulated Gene

TFs regulating RDH11 0 TFs

Transcription factors with Perturb-seq knockdown data for RDH11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RDH11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RDH11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RDH11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:67,427,006–67,427,629 268.4 kb Distal (>10kb) Multiome 288
chr14:67,514,900–67,515,814 180.4 kb Distal (>10kb) Multiome 411
chr14:67,532,784–67,533,987 162.5 kb Distal (>10kb) Multiome 684
chr14:67,541,829–67,542,290 153.8 kb Distal (>10kb) Multiome 187
chr14:67,599,595–67,600,617 95.6 kb Distal (>10kb) Multiome HiCAR 746
chr14:67,619,336–67,620,756 75.9 kb Distal (>10kb) Multiome 794
chr14:67,674,148–67,675,415 21.0 kb Distal (>10kb) Multiome 840
chr14:67,694,763–67,695,985 888 bp At TSS Multiome 742
chr14:67,704,586–67,704,750 8.8 kb Proximal (<10kb) 175
chr14:67,729,052–67,729,527 33.6 kb Distal (>10kb) Multiome 407
chr14:67,816,043–67,817,024 120.9 kb Distal (>10kb) Multiome 712
chr14:67,819,625–67,820,281 124.1 kb Distal (>10kb) Multiome 482
chr14:67,934,038–67,934,596 238.6 kb Distal (>10kb) Multiome 380

Genome Browser

Genomic view of the RDH11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:67,417,006 – 67,944,596
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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