RBPJL

recombination signal binding protein for immunoglobulin kappa J region like | RBP-L, SUH, SUHL, RBPSUHL

This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Biological processes 19 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)chromatin binding (GO:0003682)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)signal transduction (GO:0007165)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating RBPJL 0 TFs

Transcription factors with Perturb-seq knockdown data for RBPJL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBPJL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RBPJL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBPJL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:45,098,253–45,098,840	217.4 kb	Distal (>10kb) Multiome	171
chr20:45,293,338–45,294,048	22.2 kb	Distal (>10kb) Multiome	531
chr20:45,341,603–45,342,760	26.6 kb	Distal (>10kb) Multiome	696
chr20:45,347,673–45,348,799	32.5 kb	Distal (>10kb) Multiome	805
chr20:45,362,715–45,363,769	47.3 kb	Distal (>10kb) Multiome	970
chr20:45,373,703–45,374,166	58.0 kb	Distal (>10kb) Multiome	546
chr20:45,415,906–45,416,528	100.2 kb	Distal (>10kb) Multiome	911
chr20:45,469,289–45,470,949	154.7 kb	Distal (>10kb) Multiome	360

Genome Browser

Genomic view of the RBPJL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.