Enables RNA binding activity. Predicted to be involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and regulation of translation. Predicted to act upstream of or within positive regulation of gene expression. Located in cytosol and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,408,467–66,409,206 | 269.2 kb | Distal (>10kb) Multiome | 569 | |
| chr11:66,421,258–66,422,129 | 256.1 kb | Distal (>10kb) Multiome | 1190 | |
| chr11:66,438,544–66,439,241 | 238.9 kb | Distal (>10kb) Multiome HiCAR | 756 | |
| chr11:66,466,155–66,467,634 | 211.1 kb | Distal (>10kb) Multiome | 579 | |
| chr11:66,479,578–66,480,947 | 197.5 kb | Distal (>10kb) Multiome HiCAR | 937 | |
| chr11:66,510,277–66,510,954 | 167.2 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr11:66,545,631–66,547,072 | 131.7 kb | Distal (>10kb) Multiome HiCAR | 753 | |
| chr11:66,568,061–66,568,910 | 109.4 kb | Distal (>10kb) Multiome HiCAR | 392 | |
| chr11:66,592,561–66,593,452 | 84.8 kb | Distal (>10kb) Multiome | 857 | |
| chr11:66,616,078–66,617,408 | 61.4 kb | Distal (>10kb) Multiome | 1011 | |
| chr11:66,637,919–66,639,003 | 39.4 kb | Distal (>10kb) Multiome | 872 | |
| chr11:66,677,182–66,678,796 | 41 bp | At TSS Multiome | 926 | |
| chr11:66,728,259–66,728,943 | 50.6 kb | Distal (>10kb) Multiome | 275 | |
| chr11:66,744,354–66,745,291 | 66.8 kb | Distal (>10kb) Multiome | 747 | |
| chr11:66,842,896–66,843,952 | 165.5 kb | Distal (>10kb) Multiome | 843 | |
| chr11:66,855,758–66,857,980 | 178.5 kb | Distal (>10kb) Multiome | 795 | |
| chr11:66,882,995–66,883,462 | 205.4 kb | Distal (>10kb) Multiome | 277 | |
| chr11:66,957,708–66,959,038 | 280.6 kb | Distal (>10kb) Multiome | 957 |
Genomic view of the RBM4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.